MYCN drives chemoresistance in small cell lung cancer while USP7 inhibition can restore chemosensitivity.
作者： Eli Grunblatt , Nan Wu , Huajia Zhang , Xiaoli Liu , Justin P. Norton
关键词: In vivo 、 Chemotherapy 、 Genetically Engineered Mouse 、 Neuroendocrine Cancer 、 Deubiquitinating enzyme 、 Cancer research 、 Non small cell 、 Cytotoxic T cell 、 Therapeutic strategy 、 Biology
摘要: … progression and chemoresistance, … to chemoresistance. To identify therapeutic strategies for MYCN-overexpressing SCLC, we performed a genome-scale CRISPR–Cas9 sgRNA screen…
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