Cell of Origin of Small Cell Lung Cancer: Inactivation of Trp53 and Rb1 in Distinct Cell Types of Adult Mouse Lung

摘要: Small cell lung cancer (SCLC) is one of the most lethal human malignancies. To investigate cellular origin(s) this cancer, we assessed effect Trp53 and Rb1 inactivation in distinct types adult using adenoviral vectors that target Cre recombinase to Clara, neuroendocrine (NE), alveolar type 2 (SPC-expressing) cells. Using these type-restricted Adeno-Cre viruses, show loss can efficiently transform NE SPC-expressing cells leading SCLC, albeit at a lesser efficiency. In contrast, Clara were largely resistant transformation. The results indicate although serve as predominant origin SCLC subset are also endowed with ability.