Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells

作者: S. O'Gorman , N. A. Dagenais , M. Qian , Y. Marchuk

DOI: 10.1073/PNAS.94.26.14602

关键词:

摘要: The production of subtle or conditional mutations in mice through the combined use of site-specific and homologous recombination has become an increasingly widespread …

参考文章(43)
G R Askew, T Doetschman, J B Lingrel, Site-directed point mutations in embryonic stem cells: a gene-targeting tag-and-exchange strategy. Molecular and Cellular Biology. ,vol. 13, pp. 4115- 4124 ,(1993) , 10.1128/MCB.13.7.4115
J M Ahearn, M S Bartolomei, M L West, L J Cisek, J L Corden, Cloning and sequence analysis of the mouse genomic locus encoding the largest subunit of RNA polymerase II. Journal of Biological Chemistry. ,vol. 262, pp. 10695- 10705 ,(1987) , 10.1016/S0021-9258(18)61020-8
G I Evan, G K Lewis, G Ramsay, J M Bishop, Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product. Molecular and Cellular Biology. ,vol. 5, pp. 3610- 3616 ,(1985) , 10.1128/MCB.5.12.3610
R. R. Behringer, J. J. Peschon, A. Messing, C. L. Gartside, S. D. Hauschka, R. D. Palmiter, R. L. Brinster, Heart and bone tumors in transgenic mice Proceedings of the National Academy of Sciences of the United States of America. ,vol. 85, pp. 2648- 2652 ,(1988) , 10.1073/PNAS.85.8.2648
Paul Hasty, Ramiro Ramírez-Solis, Robb Krumlauf, Allan Bradley, Introduction of a subtle mutation into the hox-2.6 locus in embryonic stem cells Nature. ,vol. 350, pp. 243- 246 ,(1991) , 10.1038/350243A0
Frieder Schwenk, Udo Baron, Klaus Rajewsky, A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells. Nucleic Acids Research. ,vol. 23, pp. 5080- 5081 ,(1995) , 10.1093/NAR/23.24.5080
S O'Gorman, D. Fox, G. Wahl, Recombinase-mediated gene activation and site-specific integration in mammalian cells. Science. ,vol. 251, pp. 1351- 1355 ,(1991) , 10.1126/SCIENCE.1900642
Norman B. Hecht, Patricia A. Bower, Simon H. Waters, Pamela C. Yelick, Robert J. Distel, Evidence for haploid expression of mouse testicular genes Experimental Cell Research. ,vol. 164, pp. 183- 190 ,(1986) , 10.1016/0014-4827(86)90465-9