Mechanosensation and fluid transport in living bone.

摘要: The mechanosensory mechanisms in bone include (i) the cell system that is stimulated by external mechanical loading applied to bone; (ii) transduces a communicable signal; and (iii) systems transmit signal effector cells for maintenance of homeostasis strain adaptation structure. are osteoblasts osteoclasts. These they employ have not yet been unambiguously identified. candidate will be reviewed. It argued current theoretical experimental evidence suggests osteocytes principal bone, activated shear stress from fluid flowing through osteocyte canaliculi, electrically coupled three-dimensional network lining communications control structural adaptation. movement region vasculature canaliculi lacunae surrounding mineralized tissue accomplishes three important tasks. First, it transports nutrients buried matrix. Second, carries away waste. Third, exerts force on process, large enough sense. This probably basic mechanotransduction mechanism way which senses load subjected. flow described with particular emphasis mechanotransduction. Also communication higher frequency signals might transferred, potential small whole amplified so can respond it. One conclusions low amplitude strains maintain as effectively high strains. conclusion leads paradigm shift how treat osteoporosis cope microgravity.