Optimization of electric field parameters for the control of bone remodeling: exploitation of an indigenous mechanism for the prevention of osteopenia.

摘要: The discovery of piezoelectric potentials in loaded bone was instrumental developing a plausible mechanism by which functional activity could intrinsically influence the tissue's cellular environment and thus affect skeletal mass morphology. Using an vivo model osteopenia, we have demonstrated that resorption normally parallels disuse can be prevented or even reversed exogenous induction electric fields. Importantly, manner response (i.e., formation, turnover, resorption) is exceedingly sensitive to subtle changes field parameters. Fields below 10 microV/cm, when induced at frequencies between 50 150 Hz for 1 h/day, were sufficient maintain absence function. Reducing frequency 15 made extremely osteogenic. Indeed, this frequency-specific sinusoidal initiated more new formation than complex pulsed electromagnetic (PEMF), though inducing only 0.1% electrical energy PEMF. intensities most effective stimulation are similar those produced normal activity. This lends strong support hypothesis endogenous fields serve as critical regulatory factor both modeling remodeling processes. Delineation parameters retaining promoting will accelerate development electricity unique site-specific prophylaxis osteopenia. Because these indigenous tissue, it further suggests such treatment promote quantity quality with minimal risk consequence.