Determination of β-d-glucan and endotoxin levels in Kampo extracts.

作者: Hajime Nakae , Gaku Takahashi , Ryo Sato , Shigehiro Shibata , Shigeatsu Endo

DOI: 10.1002/AMS2.70

关键词: Medicineβ d glucanKampoLimulusDistilled waterTraditional medicine

摘要: Aims Kampo medicine is based on the use of established formulations combining natural extracts with no “brand-name” products or corresponding “generic” formulation. Due to differences in manufacturing practices, different pharmaceutical companies may contain concentrations β-d-glucan and endotoxins. The aim this study was compare endotoxins five Kampo from four companies. Methods Packages were dissolved distilled water. β-d-Glucan endotoxin measured using high-sensitivity kinetic turbidimetric Limulus assay. Results All examined found detectable Significant concentration (P = 0.0024 P = 0.0013, respectively) observed between companies. Conclusions High contents detected extracts, a large variability both among companies.

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