High Systolic and Diastolic Blood Pressure Variability Is Correlated with the Occurrence of Peripheral Arterial Disease in the First Decade following a Diagnosis of Type 2 Diabetes Mellitus: A New Biomarker from Old Measurement.

摘要: Background. To assess whether the visit-to-visit variability in blood pressure (BP) is a risk factor of peripheral arterial disease (PAD) patients with type 2 diabetes mellitus (T2DM) 10 years after diagnosis. Methods. The electronic medical records 825 patients, who were diagnosed during 2000-2002 and regularly followed for years, retrospectively reviewed. A total 53,284 clinic visit records, including analysis BP, BMI, serum glycohemoglobin, lipid profile, analyzed. Results. Patients categorized into two groups according to their systolic diastolic BP (SBP DBP, resp.). high-risk group included high SBP DBP variability; this had 1.679-fold (95% CI: 1.141-2.472, P = 0.009) increased PAD compared low-risk group. Cox regression also demonstrated that age at which T2DM, smoking status, mean creatinine level was significantly associated hazard ration 1.064 1.043-1.084, < 0.001), 1.803 1.160-2.804, 0.009), 1.208 1.042-1.401, 0.012), respectively. Conclusions. High correlated first decade following diagnosis T2DM.