Improved Polymers for Medical Implants-Polyurethanes
作者： Gordon F. Meijs , Pathiraja A. Gunatillake , Ezio Rizzardo , Simon J. McCarthy , Ronald C. Chatelier
DOI: 10.1007/978-3-642-77636-6_19
关键词: Polymer 、 Oxide 、 Soft segment 、 Polyurethane elastomer 、 Bulk polymerization 、 Ether 、 Polymer chemistry 、 Hydrolysis 、 Materials science 、 Subcutaneous implant
摘要: Polyurethane elastomers, prepared from: (i) polyether macrodiols that contain a reduced number of ether linkages compared with PTMO [poly(tetramethylene oxide)], (ii) the diisocyanate MDI [4,4’-diphenylmethanediisocyanate], and (iii) chain extender BDO [1,4-butanediol] offer enhanced stability towards oxidation hydrolysis over their PTMO-based counterparts. Polyurethane-ureas from TMXDI (m-tetramethylxylene diisocyanate), however, show decreased stability. In vivo subcutaneous implant experiments (sheep; 90 days 180 days), new MDI-based ether-reduced polyurethanes do not undergo stress cracking while materials do. The performed poorly when implanted.
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