The c-Myb Negative Regulatory Domain

摘要: It is becoming increasingly clear that c-myb plays an essential role in controlling the proliferation and differentiation of haemopoietic cells. While this has been suggested for some time based on preferential expression myb immature cells decrease its differentiation1,2, more recent loss-of-function studies have provided additional confirmation. Disruption by gene targeting results abrupt failure foetal system to develop mouse embryos3, while anti-sense oligonucleotides inhibit both normal progenitor transformed cell lines (eg ref. 4). Furthermore, ability naturally occurring5 recombinant retroviruses carrying activated forms 6,7 transform - but general, not other types vitro argues a dominant regulatory haemopoiesis. Although identified precisely, it likely, basis above evidence certain inducible leukaemic lines8-10, major function maintain proliferative state characteristics early