Constitutive versus cell cycle regulation of c-myb mRNA expression correlates with developmental stages in murine B lymphoid tumors.

摘要: The expression of c-myb mRNA is differentially regulated in murine B lymphoid tumors such that cell lymphomas and plasmacytomas contain significantly less than pre-B lymphomas. To examine the low level lymphoma line BCL1, nonessential amino acid starvation was used to block these cells a G1 state. When BCL1 were released from this block, 7- 10-fold increase detected late S phase relative exponentially growing cells. This not inhibited by aphidicolin. determine whether cycle regulation occurred during exponential growth both lines, elutriation separate populations. An seen fractions lines. In contrast, levels remained constant isolated Expression or Go serum-stimulated fibroblasts. These results indicate constitutive vs related state differentiation suggest switch may occur normal development.