Evaluation of hair roots for detection of methamphetamine and 3,4-methylenedioxymethamphetamine abuse by use of an HPLC-chemiluminescence method.

摘要: We describe the use of hair roots as a matrix for detection methamphetamine (MP) and 3,4-methylenedioxymethamphetamine (MDMA) abuse. The concentration drugs was determined in rat roots, shafts, plasma after single administration MP or MDMA, by an HPLC–peroxyoxalate chemiluminescence (PO-CL) method involving column switching. Plasma shafts were collected from male Wistar rats before (10 mg kg−1, i.p.). In addition, pigmented non-pigmented Lister hooded MDMA concentrations HPLC–PO-CL method, with satisfactory sensitivity reproducibility. 1–14 days ranged 0.038 to 0.115 ng mg−1 (n = 3). By could be detected longer (up 14 days) than it conventional biological specimens, example (~1 day), 1 10 administration. AUC1–10 (ng day mg−1) comparable (4.93 ± 2.09 vs. 6.67 1.28, n 3), whereas AUC1–14 differed significantly (1.86 0.93 4.58 0.63, P < 0.05, window detecting (or MDMA) under our conditions 1–10) days.