Kinetic Pathway of 3-Helix Micelle Formation
作者： JooChuan Ang , Benson T. Jung , He Dong , Ting Xu
DOI: 10.1021/ACS.BIOMAC.6B01831
关键词: Chemistry 、 Chemical physics 、 Alkyl 、 Folding (chemistry) 、 Non-covalent interactions 、 Circular dichroism 、 Conjugate 、 Stereochemistry 、 Helix 、 Amphiphile 、 Micelle
摘要: A subtle but highly pertinent factor in the self-assembly of hierarchical nanostructures is kinetic landscape. Self-assembly a multicomponent system requires intricate balance noncovalent interactions on similar energy scale that can result several processes occurring at different time scales. We seek to understand assemblies within an amphiphilic 3-helix peptide-PEG-lipid conjugate formation process stable micelles (3HMs). 3HM self-assembles through multiple parallel processes: helix folding, coiled-coil formation, micelle assembly, and packing alkyl chains. Our results show pathway mainly governed by two confounding factors: lateral diffusion amphiphiles form coiled-coils corona tails hydrophobic core. has exhibited desirable attributes as drug delivery nanocarrier; understanding role in...
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