Transport of drugs across the blood-brain barrier by nanoparticles.
作者： Stefanie Wohlfart , Svetlana Gelperina , Jörg Kreuter
DOI: 10.1016/J.JCONREL.2011.08.017
关键词:
摘要: The central nervous system is well protected by the blood–brain barrier (BBB) which maintains its homeostasis. Due to this many potential drugs for treatment of diseases (CNS) cannot reach brain in sufficient concentrations. One possibility deliver CNS employment polymeric nanoparticles. ability these carriers overcome BBB and produce biologic effects on was shown a number studies. Over past few years, progress understanding mechanism nanoparticle uptake into made. This appears be receptor-mediated endocytosis capillary endothelial cells. Modification surface with covalently attached targeting ligands or coating certain surfactants enabling adsorption specific plasma proteins are necessary uptake. delivery drugs, usually not able cross BBB, confirmed biodistribution studies pharmacological assays rodents. Furthermore, presence nanoparticles parenchyma visualized electron microscopy. intravenously administered biodegradable loaded doxorubicin were successfully used experimental glioblastoma. These data, together employ other macromolecules across suggest that technology holds great promise non-invasive therapy diseases.
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