Differential Serum Levels of Eosinophilic Eotaxins in Primary Sclerosing Cholangitis, Primary Biliary Cirrhosis, and Autoimmune Hepatitis

摘要: To investigate pathogenic mechanisms of primary sclerosing cholangitis (PSC), biliary cirrhosis (PBC), and autoimmune hepatitis (AIH), serum levels 26 chemokines cytokines were determined compared with patients chronic C or in healthy controls. The chemokine eotaxin-3 (E3; CCL26), which recruits eosinophils to sites inflammation, was found be highly elevated all PSC, PBC, AIH HCV Eotaxin-1 (E1; CCL11), another eosinophil-specific chemokine, PSC but reduced PBC AIH, while the macrophage-derived (MDC; CCL22) lower By incorporating interleukin (IL)-15 into a diagnostic algorithm, could each differentiated good sensitivity specificity. These findings represent first study compare level cytokine/chemokine among these related autoimmune-like liver diseases. Furthermore, our data indicate that measurement E3, E1, CCL22, IL-15 can aid diagnosis clinically challenging diseases shed light on potential underlying suggesting role for an allergic phenomenon involving eosinophils, may define them as liver-specific diseases, this open up new therapeutic avenues by abrogating action disease-associated immune modulators.