CCL22 to Activate Treg Migration and Suppress Depigmentation in Vitiligo

摘要: In vitiligo, gradual cutaneous depigmentation and cytotoxic T-cell activity against melanocytes are accompanied by a paucity of regulatory T cells (Tregs) in vitiligo patient skin, indicating that autoimmune responses not adequately held check. Thus, we sought means to repopulate skin with Tregs. We hypothesized enhanced expression CCL22 can promote Treg homing suppress depigmentation. The mouse Ccl22 gene was cloned into an vector resulting DNA used for gun treatment. Two spontaneous models different kinetics melanocyte loss were utilized, expressing tyrosinase-reactive gp100–reactive TCR transgenes. Mice subjected five treatments 6 days apart, scanned weekly thereafter, monitored activation proliferation relevant infiltration the skin. Significantly reduced 2 weeks after treatment markedly increased abundance Tregs at expense melanocyte-reactive, transgenic cells, as well IFN-γ production response cognate peptide. Continued may be necessary sustained, local immunosuppression. These findings suggest topical vitiligo.