Tumour necrosis factor-α inhibition can stabilize disease in progressive vitiligo

摘要: Tumour necrosis factor (TNF)‐α, a proinflammatory cytokine central to many autoimmune diseases, has been implicated in the depigmentation process vitiligo. We review its role vitiligo by exploring pro‐ and anti‐inflammatory properties examine effects of blocking actions with TNF‐α antagonist therapeutics reports available literature. found that inhibition halts disease progression patients progressive but that, paradoxically, treatment can be associated de novo development some when used for other conditions, particularly using adalimumab infliximab. These studies reinforce importance stating appropriate outcomes measures, as most pilot trials propose measure repigmentation, whereas halting is commonly overlooked success. conclude proven useful vitiligo, where able quash cytotoxic T‐cell‐mediated melanocyte destruction. However, lingering concern initiating will likely prevent more widespread application TNF inhibitors treat