Ccl22 Diverts T Regulatory Cells and Controls the Growth of Melanoma.

摘要: T regulatory cells (Treg) avert autoimmunity but their increased levels in melanoma confer a poor prognosis. To explore the basis for Treg accumulation melanoma, we evaluated chemokine expression patients. A 5-fold increase was documented chemoattractants CCL22 and CCL1 melanoma-affected skin versus unaffected skin, as accompanied by infiltrating FoxP3+ cells. In parallel, there ~2-fold enhancement of CCR4 circulating not effector We hypothesized that redirecting away from tumors might suppress autoimmune side-effects caused immune checkpoint therapeutics now used widely clinic. assessing this hypothesis, observed marked mice vaccinated with CCL22, repetitive vaccination sufficient to limit growth lungs animals challenged tumor cell injection, whether using prevention or treatment protocol design. The change setting could be explained conversion. Overall, our findings offered preclinical proof concept potential use delivered local injection strategy enhance efficacious response therapy while suppressing its side-effects.