Efficacy and Safety of 308-nm Monochromatic Excimer Lamp Versus Other Phototherapy Devices for Vitiligo: A Systematic Review with Meta-Analysis

摘要: Various phototherapy methods are used to treat vitiligo; however, the recent emergence of new devices has heightened debate concerning best treatment method. We aimed systematically review and meta-analyze published data comparing efficacy adverse effects monochromatic excimer lamps versus laser narrowband ultraviolet B (NB-UVB) in treating vitiligo. A systematic search PubMed, EMBASE, LILACS, Cochrane Central Register Controlled Trials (CENTRAL), clinical trials registries identified randomized controlled that included vitiligo patients, regardless age, sex, or study language. evaluated studies with NB-UVB phototherapy. The six (411 764 lesions). No found significantly different between using outcomes ≥50 % repigmentation [risk ratio (RR) = 0.97, 95 % confidence interval (CI) 0.84–1.11] ≥75 % (RR = 0.96, CI 0.71–1.30). Likewise, no significant differences (RR = 1.14, 0.88–1.48 for repigmentation; RR = 1.81, 0.11–29.52 repigmentation). Adverse were mild, including pruritus, burning sensation, dryness, none which interrupted treatment. To our knowledge, this is first safety lamp Excimer lamps, laser, all safe effective lesions. Safety, effectiveness, cost considerations when choosing CRD42014015237.