Role of apoptosis and melanocytorrhagy: a comparative study of melanocyte adhesion in stable and unstable vitiligo.

摘要: Summary Background  Apoptosis and melanocytorrhagy have been proposed as mechanisms of melanocyte disappearance although there are few controlled studies. Objectives  We undertook this project to study morphology adhesion defects in patients with stable unstable disease controls. Methods  In comparative we included seven vitiligo. cultured perilesional skin melanocytes from these vitiligo studied for morphological changes, collagen type IV caspase 3 expression. Melanocytes were also treated okadaic acid annexin V expression was then checked compared between controls vitiligo. Results  Perilesional revealed some significant changes. showed significantly low control melanocytes. Our results that staining greater the control. Conclusions  demonstrated their detachment phase, which ultimately leads apoptosis cells, whereas morphologically normal without any defects. These findings support theory primary defect underlying loss