Evaluation of thermally cross-linked superparamagnetic iron oxide nanoparticles for the changes of concentration and toxicity on tissues of Sprague-Dawley rats
作者： Jin Joo Hue , Hu-Jang Lee , Sangyong Jon , Sang Yoon Nam , Young Won Yun
DOI: 10.14405/KJVR.2014.54.4.245
关键词: Urine 、 Kidney 、 Biodistribution 、 Internal medicine 、 Toxicity 、 Tumor necrosis factor alpha 、 Materials science 、 Surgery 、 Red pulp 、 Endocrinology 、 Spleen 、 Malondialdehyde
摘要: This study was investigated the change of concentration and toxicity thermally cross-linked superparamagnetic iron oxide nanoparticles (TCL-SPION) on tissues Sprague-Dawley rats. TCL-SPION at dose 15 mg/kg body weight intravenously injected into tail vein male The fate in serum, urine observed during 28 days. Serum level maximal 0.25 h post-injection gradually declined thereafter. In addition, sinusoids liver red pulp area spleen were mainly accumulated from 0.5 to 28-day post-injection. kidney, deposition detected tubular until after injection. Malondialdehyde slightly increased with time not different that zero time. spleen, TNF- IL-6 levels TS treated those control experimental period. From results, could stay fairly long-time certain intravenous injection without toxicity. results indicated might be useful safe as a contrast for diagnosis cancer or carrier therapeutic reagents treat diseases.
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