Interactions of Some Organic Solvents: Hydrocarbons and Chloroalkene
作者： Jolanta Skowroń , Katarzyna Miranowicz-Dzierżawska , Lidia Zapór , Małgorzata Gołofit-Szymczak , Andrzej Starek
DOI: 10.1080/10803548.2001.11076475
关键词: Organic solvent 、 Metabolism 、 Toxicodynamics 、 Environmental chemistry 、 Tetrachloroethylene 、 Drop (liquid) 、 Ethylbenzene 、 Chemistry
摘要: Metabolic and toxicodynamic interactions of some organic solvents in rats repeatedly treated with medium dose levels were examined. It was shown that both n-hexane ethylbenzene significantly inhibited tetrachloroethy-lene metabolism during a 2-week period. n-Hexane tetrachloroethylene enhanced whereas suppressed only at the end experiment. Biochemical changes, especially drop level non-protein sulfhydryl groups tissues solvent mixtures, less pronounced than those observed after these chemicals administered separately. These results demonstrate metabolic between hydrocarbons chloroalkene may lead to modification biological response compounds.
sci-hub.se 参考文章(22)
Neill H. Stacey, Toxicity of mixtures of trichloroethylene, tetrachloroethylene and 1,1,1-trichloroethane: similarity of in vitro to in vivo responses. Toxicology and Industrial Health. ,vol. 5, pp. 441- 450 ,(1989) , 10.1177/074823378900500305
Soni Madhusudan, Nomiyama Hiroko, Nomiyama Kazuo, Chronic inhalation effects of tetrachloroethylene on hepatic and renal microsomal electron transport components and δ-aminolevulinic acid dehydratase in rats Toxicology Letters. ,vol. 54, pp. 207- 213 ,(1990) , 10.1016/0378-4274(90)90185-O
M. Ogata, K. Tomokuni, Y. Takatsuka, Quantitative determination in urine of hippuric acid and m- or p-methylhippuric acid, metabolites of toluene and m- or p-xylene Occupational and Environmental Medicine. ,vol. 26, pp. 330- 334 ,(1969) , 10.1136/OEM.26.4.330
Y. Takeuchi, N. Hisanaga, Y. Ono, E. Shibata, I. Saito, M. Iwata, Modification of metabolism and neurotoxicity of hexane by co-exposure of toluene. International Archives of Occupational and Environmental Health. ,vol. 65, ,(1993) , 10.1007/BF00381347
E. Elovaara, K. Engström, J. Nickels, A. Aito, H. Vainio, Biochemical and morphological effects of long-term inhalation exposure of rats to ethylbenzene. Xenobiotica. ,vol. 15, pp. 299- 308 ,(1985) , 10.3109/00498258509045364
Egon Marth, Metabolic changes following oral exposure to tetrachloroethylene in subtoxic concentrations. Archives of Toxicology. ,vol. 60, pp. 293- 299 ,(1987) , 10.1007/BF01234668
Masamitsu Iwata, Yasuhiro Takeuchi, Naomi Hisanaga, Yuichiro Ono, Changes of n-hexane neurotoxicity and its urinary metabolites by long-term co-exposure with MEK or toluene. International Archives of Occupational and Environmental Health. ,vol. 54, pp. 273- 281 ,(1984) , 10.1007/BF00378580
J R Mitchell, W R Snodgrass, J R Gillette, The role of biotransformation in chemical-induced liver injury. Environmental Health Perspectives. ,vol. 15, pp. 27- 38 ,(1976) , 10.1289/EHP.761527
Y Takeuchi, Y Ono, N Hisanaga, M Iwata, M Aoyama, J Kitoh, Y Sugiura, An experimental study of the combined effects of n-hexane and methyl ethyl ketone. Occupational and Environmental Medicine. ,vol. 40, pp. 199- 203 ,(1983) , 10.1136/OEM.40.2.199
Masana Ogata, Katsumaro Tomokuni, Hiroko Asahara, Simple microdetermination of trichloroethanol glucuronide and trichloroacetic acid in urine. Internationales Archiv f�r Arbeitsmedizin. ,vol. 32, pp. 203- 215 ,(1974) , 10.1007/BF00539337