Chronic inhalation effects of tetrachloroethylene on hepatic and renal microsomal electron transport components and δ-aminolevulinic acid dehydratase in rats
作者： Soni Madhusudan , Nomiyama Hiroko , Nomiyama Kazuo
DOI: 10.1016/0378-4274(90)90185-O
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摘要: Abstract Hepatic and renal microsomal electron transport components erythrocyte δ-aminolevulinate dehydratase were investigated in adult male rats exposed to 0, 50, 200 600 ppm tetrachloroethylene for 4 weeks. Body weight liver showed a significant decrease only the group. A dosedependent was observed at ppm. Serum transaminase activity (SGPT) an increase group only. protein content all groups except kidneys of Induction hepatic cytochrome b5 groups. However, P-450 induction slight inhibition respectively, without any alteration 50 Renal induced NADPH c reductase ppm, but no seen These results indicate that chronic inhalation higher levels alters mixed-function oxidase heme metabolism.
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