Effect of hexachlorobenzene on haem synthesis.

摘要: Several drugs are known to induce the liver microsomal mixed-function oxidase system when administered in vivo or even vitro cell culture. A sequence of events has been suggested which drug is visualized δ-aminolaevulinate synthetase, first and rate-limiting enzyme haem-biosynthetic pathway, followed by enhanced haem synthesis cytochrome P-450 content, facilitating increase drug-metabolizing activity fraction. The present studies show that fungicide hexachlorobenzene, female rats, can lead amounts rate under conditions total not appreciably altered. subsequent as well initial brought about synthetase remains constant. However, manifestation porphyria due prolonged administration accompanied a twofold activity. appears be decreased degradation enzyme.