Ability of mosapride to bind to 5-HT4 receptor in the human stomach.
作者： Sakurai-Yamashita Yasuko , Takada Kohei , Takemura Keiko , Yamashita Kimihiro , Enjoji Akihito
DOI: 10.1254/JJP.79.493
关键词: Mosapride 、 5-HT4 receptor 、 Myenteric plexus 、 Motility 、 Gastroenterology 、 Receptor 、 Internal medicine 、 Stomach 、 In vitro 、 Chemistry 、 Pharmacology 、 Guinea pig
摘要: Ability of mosapride, a gastrokinetic agent, to bind 5-HT4 receptor was examined in the stomach human and guinea pig by vitro autoradiography. [125I]SB207710 binding sites were detected muscle layer including myenteric plexus from both humans pigs, although observed more clearly densely pigs than humans. Mosapride as well SB204070 inhibited [125I]SB207710. Thus, mosapride possesses ability receptors may modulate motility, case stomach.
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