The parathyroid calcium receptor: a novel therapeutic target for treating hyperparathyroidism.
作者： Edward F. Nemeth , Michael E. Steffey , John Fox
DOI: 10.1007/BF00866757
关键词: Calcium metabolism 、 Calcium-sensing receptor 、 Medicine 、 Internal medicine 、 Endocrinology 、 Calcitonin receptor 、 Parathyroid chief cell 、 Parathyroid hormone 、 Calcimimetic 、 Secondary hyperparathyroidism 、 Hyperparathyroidism
摘要: Parathyroid cells, C-cells, and certain cells in the kidney express a cell surface calcium (Ca2+) receptor which enables these to detect respond changes concentration of extracellular Ca2+. This protein is member G protein-coupled superfamily shares limited sequence homology only with metabotropic glutamate receptors. The Ca2+ primary physiological mechanism regulating secretion parathyroid hormone (PTH) plays pivotal role maintaining systemic homeostasis. Compounds that act as agonists are called calcimimetics because they mimic or potentiate effects on function. NPS R-568 small organic calcimimetic compound acts positive allosteric modulator increase sensitivity activation by In normal rats, orally administered decreases plasma levels PTH and, at higher doses, increases calcitonin. circulating two hormones explain hypocalcemia caused this compound. also effectively lowers humans rat models secondary hyperparathyroidism. Calcimimetic compounds target provide novel therapeutic approach for treating
springer.com
sci-hub.se 参考文章(24)
E.F. Nemeth, A. Scarpa, SPERMINE EVOKES THE RAPID MOBILIZATION OF CELLULAR Ca2+ IN PARATHYROID CELLS Calcium-Binding Proteins in Health and Disease. pp. 33- 35 ,(1987) , 10.1016/B978-0-12-521040-9.50009-7
E.F. Nemeth, A. Scarpa, Rapid mobilization of cellular Ca2+ in bovine parathyroid cells evoked by extracellular divalent cations. Evidence for a cell surface calcium receptor. Journal of Biological Chemistry. ,vol. 262, pp. 5188- 5196 ,(1987) , 10.1016/S0021-9258(18)61172-X
E. M. Brown, Extracellular Ca2+ sensing, regulation of parathyroid cell function, and role of Ca2+ and other ions as extracellular (first) messengers Physiological Reviews. ,vol. 71, pp. 371- 411 ,(1991) , 10.1152/PHYSREV.1991.71.2.371
E.F. Nemeth, Regulation of cytosolic calcium by extracellular divalent cations in C-cells and parathyroid cells Cell Calcium. ,vol. 11, pp. 323- 327 ,(1990) , 10.1016/0143-4160(90)90033-Q
Donald J. Sherrard, Gavril Hercz, York Pei, Norma A. Maloney, Celia Greenwood, Arif Manuel, Carl Saiphoo, Stanley S. Fenton, Gino V. Segre, The spectrum of bone disease in end-stage renal failure—An evolving disorder Kidney International. ,vol. 43, pp. 436- 442 ,(1993) , 10.1038/KI.1993.64
Raymond Ardaillou, Pierre Sizonenko, Alain Meyrier, Gabriel Vallée, Christian Beaugas, Metabolic clearance rate of radioiodinated human calcitonin in man Journal of Clinical Investigation. ,vol. 49, pp. 2345- 2352 ,(1970) , 10.1172/JCI106453
Edward Brown, Peter Enyedi, Meryl LeBoff, Jane Rotberg, Joseph Preston, Chu Chen, High extracellular Ca2+
and Mg2+
stimulate accumulation of inositol phosphates in bovine parathyroid cells FEBS Letters. ,vol. 218, pp. 113- 118 ,(1987) , 10.1016/0014-5793(87)81029-3
Edward M. Brown, Gerardo Gamba, Daniela Riccardi, Michael Lombardi, Robert Butters, Olga Kifor, Adam Sun, Matthias A. Hediger, Jonathan Lytton, Steven C. Hebert, Cloning and characterization of an extracellular Ca 2+ -sensing receptor from bovine parathyroid Nature. ,vol. 366, pp. 575- 580 ,(1993) , 10.1038/366575A0
EDWARD M. BROWN, ROBERT BUTTERS, CRAIG KATZ, OLGA KIFOR, Neomycin mimics the effects of high extracellular calcium concentrations on parathyroid function in dispersed bovine parathyroid cells. Endocrinology. ,vol. 128, pp. 3047- 3054 ,(1991) , 10.1210/ENDO-128-6-3047
Charlotte H. Søgaard, Carl Christian Danielsen, Eivind B. Thorling, Lis Mosekilde, Long-term exercise of young and adult female rats: effect on femoral neck biomechanical competence and bone structure. Journal of Bone and Mineral Research. ,vol. 9, pp. 409- 416 ,(2009) , 10.1002/JBMR.5650090317