SPERMINE EVOKES THE RAPID MOBILIZATION OF CELLULAR Ca2+ IN PARATHYROID CELLS

摘要: This chapter discusses the initial action of extracellular Ca 2+ that involves interaction with a -binding protein on surface parathryoid cell and activation this receptor is intimately linked to regulation parathyroid hormone (PTH) secretion. Dissociated bovine cells loaded fura-2 show transient followed by lower yet sustained increases in [Ca ] response small concentration . Like cytosolic transients elicited divalent cations, those evoked spermine arise from mobilization cellular The results appears mimic effects evokes rapid cells. competitive interactions beteen cations can be taken as evidence acts at receptor. may even more promiscuous than previously supposed, might respond not only various di- trivalent but also certain organic polycations. An ligand, which chemically modified, aid isolation characterization