Convenient one-step synthesis of a medicinally relevant benzopyranopyridine system
作者： Nikolai M. Evdokimov , Artem S. Kireev , Andrey A. Yakovenko , Mikhail Yu. Antipin , Igor V. Magedov
DOI: 10.1016/J.TETLET.2006.10.110
关键词: Chemistry 、 Organic chemistry 、 Combinatorial chemistry 、 One-Step 、 Malononitrile 、 Pyridine 、 Biochemistry 、 Drug discovery
摘要: Benzopyrano[2,3-b]pyridine is an important privileged medicinal scaffold. A three-component reaction of salicylaldehydes, thiols and 2 equiv malononitrile that leads to the formation a series compounds incorporating 2,4-diamino-3-cyano-5-sulfanylbenzopyrano[2,3-b]pyridine framework described. proposed mechanism with supporting experimental data presented.
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