Multicomponent Synthesis of 2,3-Dihydrochromeno[4,3-d]pyrazolo[3,4-b]pyridine-1,6-diones: A Novel Heterocyclic Scaffold with Antibacterial Activity.
作者： Liliya V. Frolova , Indranil Malik , Pavel Y. Uglinskii , Snezna Rogelj , Alexander Kornienko
DOI: 10.1016/J.TETLET.2011.10.012
关键词: Antibacterial activity 、 Scaffold 、 Chemistry 、 Pyridine 、 Combinatorial chemistry 、 Heterocyclic amine
摘要: A multicomponent reaction of 3-aminopyrazol-5-ones with substituted salicylic aldehydes and acetylacetic ester leading to the formation novel 2,3-dihydrochromeno[4,3-d]pyrazolo[3,4-b]pyridine-1,6-diones was discovered. The elucidation scope revealed that 5-aminopyrazoles, 3-amino-1,2,4-triazoles 6-aminouracil could be used as heterocyclic amine component. Selected products were found possess notable antibacterial activities.
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