Compositions and methods for enhanced mucosal delivery of growth hormone
作者： Jorge C. De Meireles , Shyam Vangala , Malini Gupta , Steven C. Quay
DOI:
关键词: Endocrinology 、 Blood plasma 、 Cmax 、 Nasal administration 、 Growth hormone 、 Hormone 、 Subcutaneous injection 、 Medicine 、 Internal medicine 、 Hepatic portal vein 、 Human growth hormone
摘要: Pharmaceutical formulations are described comprising at least one growth hormone and or more intranasal delivery-enhancing agents for enhanced nasal mucosal delivery of the hormone. In aspect, methods provide to blood plasma, example, by yielding a peak concentration (Cmax) in an hepatic portal vein plasma subject that is 20% greater compared following administration same dose subcutaneous injection. Exemplary within invention utilize human as
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