Accelerated CD8+ T-cell memory after dendritic cell vaccination

摘要: Disclosed are compositions and methods for Here, it is shown that vaccination with peptide-coated dendritic cells (DC) generated antigen-(Ag) specific CD8+ T-cells the phenotype function of memory as early 4-6 days after immunization. These memory-like underwent vigorous secondary expansion, resulting in rapid generation elevated T-cell numbers increased protective immunity, response to a variety booster immunizations. However, concurrent inflammation prevented by DC Thus, vaccination, absence overt inflammation, accelerated cell dramatically reduced interval required amplification numbers.