Target peptides for immunotherapy and diagnostics
作者： Angela Zarling , Mark Cobbold , Kara L. Cummings , Donald F. Hunt , Stacy A. Malaker
DOI:
关键词: Disease 、 Immune system 、 HLA-A 、 Immunotherapy 、 Medicine 、 Cancer 、 Immunology 、 Antibody 、 T cell 、 Major histocompatibility complex
摘要: A set of target peptides are presented by HLA A*0101, A*0201, A*0301, B*4402, B*2705, B*1402, and B*0702 on the surface disease cells. They envisioned to among other things (a) stimulate an immune response proliferative disease, e.g., cancer, (b) function as immunotherapeutics in adoptive T cell therapy or a vaccine, (c) facilitate antibody recognition tumor boundaries surgical pathology samples, (d) act biomarkers for early detection and/or diagnosis (e) targets generation antibody-like molecules which recognize target-peptide/MHC complex.
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