A comprehensive gas chromatography coupled to high resolution mass spectrometry based method for the determination of polybrominated diphenyl ethers and their hydroxylated and methoxylated metabolites in environmental samples.
作者： S. Lacorte , M.G. Ikonomou , M. Fischer
DOI: 10.1016/J.CHROMA.2009.11.024
关键词: Mass spectrometry 、 Chemistry 、 Gas chromatography 、 Gel permeation chromatography 、 Polybrominated diphenyl ethers 、 Chromatography 、 Column chromatography 、 Derivatization 、 Gas chromatography–mass spectrometry 、 Resolution (mass spectrometry)
摘要: Abstract We report here an efficient and comprehensive analytical methodology based on gas chromatography with high resolution mass spectrometry (GC–HRMS) to simultaneously determine PBDEs from mono deca brominated hydroxy (OH-) methoxy (MeO-) PBDE metabolites in environmental samples, particularly, sediment, fish tissue milk. Among a number of extraction clean-up methods tested, pressurized liquid followed by gel permeation florisil proved be simple, robust optimized so that all target analytes (parent compounds metabolites) were collected single fraction. Extracts analyzed GC–HRMS identify PBDEs. Following, the same extracts derivatized re-analyzed 11 35 non-target OH- MeO-PBDEs. Monitoring M+ for MeO-PBDEs [M−CH2CO]+ ions OH-PBDEs at 10,000 permitted unequivocal identification matrices examined. The method was validated terms accuracy, precision, detection limits long-term stability. precision obtained this between 0.3 17%, quantification lower than 3.28 pg/g dry weight, 20.5 41.4 pg/g lipid weight milk fish, respectively. applied three matrices.
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