Rush Immunotherapy: Experience with a One-Day Schedule

摘要: Introduction Rush immunotherapy is a method for rapidly desensitizing patients to inhalant allergens. The frequency of systemic reactions during rush similar conventional when premedication used. most rapid protocol reported date requires one and one-half days which inconvenient clinic schedules. To improve this situation decrease the cost giving immunotherapy, we have developed 1-day protocol. Methods For ongoing study, 22 allergic received consisting 8 injections over 6 hours followed by 2 observation in an outpatient clinic. Five had rhinitis rest asthma, 7 whom were steroid-dependent. All premedicated with astemizole, ranitidine, prednisone 3 including day peak expiratory flow rates monitored. Results Systemic seen 5 (23%). They occurred following sixth injection (1), seventh (2), or final (2) consisted primarily pulmonary symptoms episode mild anaphylaxis. A reaction was only 1 steroid-dependent asthmatic patient. local preceded but reached maintenance dose day. responded epinephrine all could go home after immunotherapy. Only patient months Conclusions One-day tolerated rate comparable able reach sooner than weekly With refinement procedure, may become widely used allergens, make immunotherapyless expensive more convenient.