Effect of rush immunotherapy in house-dust-mite (HDM)-sensitive adult bronchial asthma : changes in in vivo and in vitro responses to HDM
作者： Makoto NAGATA , Hideaki YAMAMOTO , Kazuaki TABE , Isao KIMURA , Isao HOUYA
DOI: 10.2169/INTERNALMEDICINE.32.702
关键词: Allergen 、 Allergy 、 Asthma 、 Medicine 、 In vivo 、 Immunopathology 、 Antibody 、 Immunology 、 Inhalation 、 House dust mite
摘要: An open study was conducted to evaluate the changes in vivo and vitro responses house-dust-mite (HDM) after rush immunotherapy (RI). A 7-day RI protocol using an extract containing HDM allergen administered 12 subjects with HDM-sensitive asthma, effects on bronchial responsiveness serum antibody levels were evaluated up 16 or 20 weeks RI. The of HDM-specific IgG, IgG1 IgG4 antibodies significantly elevated from 4 8 Provocative doses causing a 20% fall FEV1 (PD20) by inhalation all at There high correlation between increase log-PD20 ratio (r=0.68, p<0.05). results suggest that elicits improvement allergen-specific within relatively short period.(Internal Medicine 32: 702-709, 1993)
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