Targeting viruses using a modified sindbis glycoprotein
作者： Patricia Whitaker-Dowling , Ira Bergman
DOI:
关键词: Cell 、 Virus 、 Virology 、 Glycoprotein 、 Ligand molecule 、 Cancer cell 、 Biology 、 Infected cell 、 Genetic enhancement 、 Immune system
摘要: The present invention relates to viruses that are engineered contain a surface ligand molecule which targets the virus cell of interest. In particular non-limiting embodiments, interest is desirably ablated and may be cancer cell, an infected exhibiting non-malignant proliferative disorder, or immune system. Alternatively, target for gene therapy.
lens.org 参考文章(97)
Joseph D. Rosenblatt, Sherie L. Morrison, Seung Uon Shin, Manuel L. Penichet, Sharon L. Sampogna, Pia Maria Challita, In vivo properties of three human HER2/neu-expressing murine cell lines in immunocompetent mice. Laboratory Animal Science. ,vol. 49, pp. 179- 188 ,(1999)
Myrna R. Rosenfeld, Ira Bergman, Laura Schramm, Judith A. Griffin, Michael G. Kaplitt, Patricio I. Meneses, Adeno-associated viral vector gene transfer into leptomeningeal xenografts. Journal of Neuro-oncology. ,vol. 34, pp. 139- 144 ,(1997) , 10.1023/A:1005702228721
Akihiro Tsuboi, Yoshihiro Oka, Hiroyasu Ogawa, Olga A. Elisseeva, Hanfen Li, Kotomi Kawasaki, Katsuyuki Aozasa, Tadamitsu Kishimoto, Keiko Udaka, Haruo Sugiyama, Cytotoxic T-Lymphocyte Responses Elicited to Wilms' Tumor Gene WT1 Product by DNA Vaccination Journal of Clinical Immunology. ,vol. 20, pp. 195- 202 ,(2000) , 10.1023/A:1006637529995
Ainhoa Perez-Diez, Paul J. Spiess, Nicholas P. Restifo, Polly Matzinger, Francesco M. Marincola, Intensity of the vaccine-elicited immune response determines tumor clearance. Journal of Immunology. ,vol. 168, pp. 338- 347 ,(2002) , 10.4049/JIMMUNOL.168.1.338
Hong-Ming Hu, Hauke Winter, Jun Ma, Michael Croft, Walter J. Urba, Bernard A. Fox, CD28, TNF receptor, and IL-12 are critical for CD4-independent cross-priming of therapeutic antitumor CD8+ T cells. Journal of Immunology. ,vol. 169, pp. 4897- 4904 ,(2002) , 10.4049/JIMMUNOL.169.9.4897
David F. Stojdl, Brian Lichty, Shane Knowles, Ricardo Marius, Harold Atkins, Nahum Sonenberg, John C. Bell, Exploiting tumor-specific defects in the interferon pathway with a previously unknown oncolytic virus. Nature Medicine. ,vol. 6, pp. 821- 825 ,(2000) , 10.1038/77558
David H. Kirn, Carla C. Heise, Angelica M. Williams, Shirley Xue, Meisa Propst, Intravenous administration of ONYX-015, a selectively replicating adenovirus, induces antitumoral efficacy. Cancer Research. ,vol. 59, pp. 2623- 2628 ,(1999)
Yumiko Hirose, Fumiko Arakawa, Yoshihiro Tomita, Masahide Kuroki, Liao Shao-Xi, Motomu Kuroki, Pranay D. Khare, Ken Nakamura, Specifically targeted killing of carcinoembryonic antigen (CEA)-expressing cells by a retroviral vector displaying single-chain variable fragmented antibody to CEA and carrying the gene for inducible nitric oxide synthase. Cancer Research. ,vol. 61, pp. 370- 375 ,(2001)
Elizabeth M. Jaffee, R. Todd Reilly, Katharine H. Dixon, Jean Pascal H. Machiels, William J. Muller, Anne M. Ercolini, Colin E. Kane, Francesca I. Okoye, Morris B.C. Gottlieb, HER-2/neu is a tumor rejection target in tolerized HER-2/neu transgenic mice Cancer Research. ,vol. 60, pp. 3569- 3576 ,(2000)
Gregory L. Beatty, Yvonne Paterson, IFN-γ-Dependent Inhibition of Tumor Angiogenesis by Tumor-Infiltrating CD4+ T Cells Requires Tumor Responsiveness to IFN-γ Journal of Immunology. ,vol. 166, pp. 2276- 2282 ,(2001) , 10.4049/JIMMUNOL.166.4.2276