Targeting QseC Signaling and Virulence for Antibiotic Development
作者： D. A. Rasko , C. G. Moreira , D. R. Li , N. C. Reading , J. M. Ritchie
关键词: Antibacterial agent 、 Virulence 、 Microbiology 、 Pathogen 、 Regulation of gene expression 、 Signal transduction 、 Phosphorylation 、 Histidine kinase 、 Autophosphorylation 、 Biology
摘要: Many bacterial pathogens rely on a conserved membrane histidine sensor kinase, QseC, to respond host adrenergic signaling molecules and signals in order promote the expression of virulence factors. Using high-throughput screen, we identified small molecule, LED209, that inhibits binding preventing its autophosphorylation consequently inhibiting QseC-mediated activation gene expression. LED209 is not toxic does inhibit pathogen growth; however, this compound markedly several vitro vivo animals. Inhibition offers strategy for development broad-spectrum antimicrobial drugs.
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