VEGF , FGF1 , FGF2 and EGF gene polymorphisms and psoriatic arthritis

摘要: Angiogenesis appears to be a first-order event in psoriatic arthritis (PsA). Among angiogenic factors, the cytokines vascular endothelial growth factor (VEGF), epidermal (EGF), and fibroblast factors 1 2 (FGF1 FGF2) play central role initiation of angiogenesis. Most these have been shown upregulated or associated with psoriasis, rheumatoid (RA) ankylosing spondylitis (AS). As diseases share common susceptibility associations PsA, investigation is warranted. Two hundred fifty-eight patients PsA 154 ethnically matched controls were genotyped using Sequenom chip-based MALDI-TOF mass spectrometry platform. Four SNPs VEGF gene, three EGF gene one SNP each FGF1 FGF2 genes evaluated. Statistical analysis was performed Fisher's exact test, Cochrane-Armitage trend test. Associations haplotypes estimated by weighted logistic models, where individual haplotype estimates obtained Phase v2.1. We observed an increased frequency T allele +936 (rs3025039) control subjects when compared our [Fisher's p-value = 0.042; OR 0.653 (95% CI: 0.434, 0.982)]. Haplotyping markers revealed no significant associations. The may act as protective development PsA. Further studies regarding pro-angiogenic are