Combined Effects of Chemotherapy and Immunity against Leukemia L1210 in DBA/2 Mice

摘要: Summary DBA/2 mice inoculated with the strain-specific leukemia L1210 survived more than 50 days as a result of combined effects drug treatments and immunity. Differences in immunogenicity were noted among 3 sublines mouse strain. The therapeutic occurred also which is weakly immunogenic at doses are immunodepressant per se . More 60% Ha-DD longer after 4,4′-diacetyl-diphenyl-urea-bis(guanylhydrazone)dimethanesulfonate arabinosylcytosine. cured resistant to reimplantation L1210. This resistance was transferred previously not exposed by inoculation immune serum, spleen or lymph node cells. thereapeutic against reduced preirradiated hosts. sensitized repeated immunization X-ray-killed leukemic incidence chemotherapeutically induced cures about 20 5% DBA/2J DBA/2Cr respectively. Also, these Synergism between drugs either passive adoptive immunity seen both DBA/2Ha-DD serum cells from hyperimmune mice. Accelerated rejection skin could be grafts. survival reciprocal grafts prolonged 2 exerting antileukemic pretreatments same doses.