Measures of stored red blood cell quality

摘要: Blood banking underpins modern medical care, but blood storage, necessary for testing and inventory management, reduces the safety efficacy of individual units red cells (RBCs). Stored RBCs are damaged by accumulation their own waste products, enzymatic oxidative injury, metabolically programmed cell death. These chemical activities lead to a complex RBC storage lesion that includes haemolysis, reduced in vivo recovery, energy membrane loss, altered oxygen release, adenosine tri-phosphate nitric oxide secretion, shedding toxic products. products include lysophospholipids can cause transfusion-related acute lung free iron potentiate infections inflammation, shed microvesicles scavenge inflammation thrombosis. However, most obvious negative outcomes uncommon appear be related exceptionally bad units. Generally, quality stored is highly conditions so refrigerator temperature, intact bags, residual leucocyte counts visible haemolysis remain excellent general measures. Specific biochemical measures, such as 5'-triphosphate (ATP) 2,3-diphosphoglycerate (DPG) concentrations, calcium potassium content or lipid breakdown require specialized measures not widely available, involve destructive generally reflect only part lesion. This review describes number components measurement attempts access utility