Fabrication of Gelatin-Based Electrospun Composite Fibers for Anti-Bacterial Properties and Protein Adsorption.
作者： Ya Gao , Yingbo Wang , Yimin Wang , Wenguo Cui
DOI: 10.3390/MD14100192
关键词: Adsorption 、 Protein adsorption 、 Electrospinning 、 Chitosan 、 Chemical engineering 、 Fiber 、 Composite number 、 Membrane 、 Polymer chemistry 、 Materials science 、 Gelatin
摘要: A major goal of biomimetics is the development chemical compositions and structures that simulate extracellular matrix. In this study, gelatin-based electrospun composite fibrous membranes were prepared by electrospinning to generate bone scaffold materials. The multicomponent fibers fabricated using co-electrospinning, chitosan (CS), gelatin (Gel), hydroxyapatite (HA), graphene oxide (GO) successfully for multi-function characteristics biomimetic scaffolds. effect component concentration on fiber morphology, antibacterial properties, protein adsorption investigated. Composite exhibited effective activity against Staphylococcus aureus Escherichia coli. study observed have higher capacities bovine serum albumin (BSA) at pH 5.32–6.00 than 3.90–4.50 or 7.35. surface increased as initial BSA increased. reached equilibrium 20 min. These results specific applications materials, broad implications in field tissue engineering.
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