A sulfonated PEEK/PCL composite nanofibrous membrane for periosteum tissue engineering application

摘要: The favorable mechanical property and regenerative capacity of bone graft are extremely important for the reconstruction large defect. Polyetheretherketone (PEEK) has tailored elastic modulus to natural cortical bone, while its application is limited by bio-inert surface. Tissue-engineered periosteum exhibits improved osteogenesis-inducing capacity. However, present artificial difficult effectively anchor grafts. use PEEK-based nanomembrane may be a promising candidate integrate with PEEK without problem, which not been reported until now. In this work, series fluorinated polymers were successfully synthesized electrospun into nanofibers. chemical structure, morphology, thermal stability, wettability strength s-PEEK membranes investigated. Then, novel flexible nanocomposite membrane tissue-engineered based on fibrous sulfonated (s-PEEK) polycaprolactone (PCL) was prepared. functional properties evaluated accordingly. s-PEEK/PCL composite showed superior hydrophilic better ductility than pure film. protein adsorption also evaluated, suggesting elevated bioactivity membranes. Finally, mineralized homogenous thinner calcium phosphate layer, indicating potential improve osteogenic response.