Human dendritic cell subsets and function in health and disease.

摘要: The method of choice for the development new vaccines is to target distinct dendritic cell subsets with antigen in vivo and harness their function situ enhance cell-mediated immunity or induce tolerance specific antigens. innate functions cells themselves may also be targeted by inhibitors activators that would a such as interferon production, potentially important autoimmune disease chronic viral infections. Importantly targeting requires detailed knowledge both surface phenotype each subset, including how they respond different types vaccine adjuvants, ability produce soluble mediators process present antigens priming naive T cells. This review summarizes our functional attributes human steady state upon activation roles disease.