Concurrent loss of co-stimulatory molecules and functional cytokine secretion attributes leads to proliferative senescence of CD8(+) T cells in HIV/TB co-infection.

摘要: The role of T-cell immunosenescence and functional CD8(+) responses in HIV/TB co-infection is unclear. We examined correlated surrogate markers HIV disease progression with immune activation, differentiation using pools co-infected, HIV-infected healthy controls. Our investigations showed increased plasma viremia reduced CD4/CD8 ratio co-infected subjects relative to HIV-infected, also a closer association changes the expression CD38, cyclic ADP ribose hydrolase CD57, which were consistently expressed on late-senescent T cells. Up-regulation CD57 CD38 directly proportional lack co-stimulatory cells, besides diminished CD127 (IL-7Rα) CD57(+)CD4(+) Notably, intracellular IFN-γ, perforin granzyme B levels HIV-specific cells diminished. Intracellular gag p24-specific significantly co-infection. suggest that HIV-TB contributes senescence associated chronic could be due insufficiency