Drug Discovery Testing Compounds in Patient Samples by Automated Flow Cytometry.
作者： Pilar Hernández , Julián Gorrochategui , Daniel Primo , Alicia Robles , José Luis Rojas
关键词: Drug discovery 、 In patient 、 Flow cytometry 、 Drug 、 Oncology 、 Ex vivo 、 Precision medicine 、 Internal medicine 、 Bone marrow 、 Cancer treatment 、 Medicine
摘要: Functional ex vivo assays that predict a patient’s clinical response to anticancer drugs for guiding cancer treatment have long been goal, but few yet proved be reliable. To address this, we developed an automated flow cytometry platform drug screening evaluates multiple endpoints with robust data analysis system can capture the complex mechanisms of action across different compounds. This system, called PharmaFlow, is used test peripheral blood or bone marrow samples from patients diagnosed hematological malignancies. use whole sample, retaining all microenvironmental components contained in offer approach testing may give results are clinically relevant. new help patients’ existing treatments under development, malignancies other tumors. In addition, relevant biomarkers identified determine sensit...
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