Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice
作者： Catherine Postic , Jean Girard
DOI: 10.1172/JCI34275
关键词: Insulin resistance 、 Fatty liver 、 Type 2 diabetes 、 Biology 、 Internal medicine 、 Fatty acid synthesis 、 Nonalcoholic fatty liver disease 、 Steatosis 、 Pathogenesis 、 Cirrhosis 、 Endocrinology
摘要: Nonalcoholic fatty liver disease (NAFLD) is associated with obesity, insulin resistance, and type 2 diabetes. NAFLD represents a large spectrum of diseases ranging from (i) fatty liver (hepatic steatosis);(ii) steatosis with inflammation and necrosis; and (iii) cirrhosis. Although the molecular mechanism leading to the development of hepatic steatosis in the pathogenesis of NAFLD is complex, recent animal models have shown that modulating important enzymes in fatty acid synthesis in liver may be key for the treatment of NAFLD …
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