Glutamate, nitric oxide and cell-cell signalling in the nervous system
作者： John Garthwaite
DOI: 10.1016/0166-2236(91)90022-M
关键词: Neurotransmitter 、 Excitatory postsynaptic potential 、 Astrocyte 、 Biology 、 Nitric oxide 、 7-Nitroindazole 、 Postsynaptic potential 、 Glutamate receptor 、 Nervous system 、 Cell biology 、 Neuroscience
摘要: Nitric oxide (NO) is a recently discovered and highly unorthodox messenger molecule. Current evidence indicates that, in the CNS, NO produced enzymatically postsynaptic structures response to activation of excitatory amino acid receptors. It then diffuses out act on neighbouring cellular elements, probably presynaptic nerve endings astrocyte processes. In several peripheral nerves, quite possibly parts CNS as well, might be formed presynaptically thus neurotransmitter. both cases, major action activate soluble guanylate cyclase so raise cGMP levels target cells.
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