2 Pyruvate Kinase
作者： L. Engström , P. Ekman , E. Humble , Ö. Zetterqvist
DOI: 10.1016/S1874-6047(08)60253-X
关键词: MAP kinase kinase kinase 、 MAP2K7 、 Pyruvate kinase 、 PKM2 、 Cyclin-dependent kinase 2 、 Pyruvate dehydrogenase kinase 、 Biochemistry 、 Biology 、 Pyruvate dehydrogenase phosphatase 、 Mitogen-activated protein kinase kinase
摘要: Publisher Summary The chapter discusses the regulatory phosphorylation of pyruvate kinase type L by cAMP-dependent protein kinase. It also briefly role liver in regulation glycolysis and gluconeogenesis. alters kinetic behavior enzyme, including influence allosteric effectors on enzyme. dephosphorylation is mainly accounted for phosphatase-2A. For enzyme kinase, structural requirements reside amino acid sequence phosphorylatable site. As its counterpart liver, kidney kinase—type L—is phosphorylated serine residues upon incubation with ATP changes activity are reversed phosphoprotein phosphatase. In vivo isolated hepatocytes, subject to same functional presence glucagon or cAMP as purified when it incubated ATP. degree appears correlate fairly well properties vitro hormonal response level intact cells.
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