Role of Cysteine Cathepsins in Extracellular Proteolysis

摘要: Cysteine cathepsins are lysosomal proteases with housekeeping as well highly specialized functions. Although their activities optimal at acidic and reducing conditions, can significantly contribute to the degradation of extracellular matrix. This may happen under physiological conditions in cathepsin K-mediated bone resorption or pathological conditions. Extracellular matrix occur extracellularly by secretion intracellularly following endocytosis material. Under is safeguarded against its neutral pH, oxidative environment, high levels potent endogenous inhibitors. However, these barriers be overcome pericellular acidification pathophysiologically reduced anticathepsin concentrations. Whereas metalloproteases primarily responsible for homeostasis matrix, cysteine destruction disease The development inhibitors anti matrix-degrading drugs appears a successful strategy.