Lysosomal enzymes, cathepsins in brain tumour invasion

摘要: The expression patterns of different classes peptidases in central nervous system (CNS) tumours have been most extensively studied astrocytomas and meningiomas. Although the two types are very respects, both may invade locally into normal brain. This process invasion includes increased synthesis secretion lysosomal proteolytic enzymes – cathepsins. Aspartic endopeptidase cathepsin (Cat) D levels were found to be elevated high-grade astrocytoma partial inhibition glioblastoma cell by anti-Cat antibody suggests that enzyme activity is involved process. Several studies on cysteine (CP) Cat B gliomas agreed transcript abundance, protein level cultures compared with low-grade Moreover, glioma biopsies correlated evidence clinical it has demonstrated tumour cells endothelial can serve as a new biological marker for prognosis patients. A high was also diagnostic invasive meningioma, distinguishing between histomorphologically benign, but meningiomas noninvasive, so-called clear–benign L significantly Specific antibodies antisense RNA transfection lowered invasion. In less-significant than B. contrast cathepsins, activities endogenous peptidase inhibitors (CPIs), including stefins, cystatins kininogens, higher benign atypical meningioma extracts malignant astrocytoma. However, low stefins tissues. Further balance endopeptidases (CPs) CPIs would improve application cathepsins prognosis, which lead more-informed therapeutic strategies.