A TPX2 Proteomimetic Has Enhanced Affinity for Aurora-A Due to Hydrocarbon Stapling of a Helix.
作者： Yana K. Rennie , Patrick J. McIntyre , Tito Akindele , Richard Bayliss , Andrew G. Jamieson
DOI: 10.1021/ACSCHEMBIO.6B00727
关键词: Alpha helix 、 Biochemistry 、 Biophysics 、 Isothermal titration calorimetry 、 Linker 、 Allosteric regulation 、 Drug discovery 、 Helix 、 Autophosphorylation 、 Plasma protein binding 、 Biology
摘要: … To probe the structural requirements of the extended region of TPX2 Ser7 TPX2 –Ser21 TPX2 region, we synthesized a TPX2 … Circular dichroism spectroscopy confirmed that the native …
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